Last medically reviewed on March 31, 2020. Asthma research helps us understand how the disease is caused, how it develops and how it is best treated. Asthma is a disease in which the airways swell up and tighten, making it hard to catch your breath. They report their findings today in leading journal Nature Communications. The researchers have uncovered a critical role for a protein (Caspase-11), which had previously never been implicated in the disease. Caspase-11 is a protein with an important role in defending against bacteria, but the team in Trinity has found that when it is over-active it can provoke a damaging inflammatory reaction. We have found that Caspase-11 is a key driver of inflammation in the airways in asthma. Researchers from Trinity College Dublin have made a breakthrough that may eventually lead to improved therapeutic options for people living with asthma. 26th February 2020 26th February 2020 Researchers from Trinity have made a breakthrough that may eventually lead to improved therapeutic options for people living with asthma. They reported their findings in leading journal Nature Communications. Dr. Zaslona said: "Caspase-11 can cause cells to die, which is a very inflammatory event as the cells then release their contents, which can irritate tissues in our body. Valve Surgery. Our work suggests that Caspase-11 is sensing these noxious things and causing disease.”, Professor O’Neill said: “Caspase-11—or it’s human equivalent, which is Caspase-4—has never been implicated in asthma before so we think it holds great promise as a possible target for new drugs to treat this common, debilitating disease.”. The disease can be of various severity ranging from very mild to severe. Thank you for taking your time to send in your valued opinion to Science X editors. May 26, 2020 June 13, 2020 TalkingAsthma 2 min read . This document is subject to copyright. (accessed December 12, 2020). The researchers have uncovered a critical role for a protein (Caspase-11), which had previously never been implicated in the disease. This asthma and allergy breakthrough you are about to discover on this page has been scientifically verified and proven by doctors to reverse disease. Two amazing diabetes breakthroughs of 2020 The 2020 is being called a cursed year, thanks to the coronavirus outbreak, which is identified as the worst pandemic seen in over a century. Breakthrough research breathes hope into a new treatment for asthma 19/08/2020 An international team of scientists, led by the Universities of Leicester and Glasgow, has announced findings that could pave the way to a new treatment for asthma and chronic obstructive pulmonary disease (COPD). 2019. For some patients, the effects are mild. Researchers from Trinity College Dublin have made a breakthrough that may eventually lead to improved therapeutic options for people living with asthma. The severe form of the disease only affects about 5% of patients but is responsible for a large component of the overal … As the air sacs in your lung get larger, your lung can fill with too much air every time … Learn about asthma causes, attacks, symptoms, risk factors, diagnoses, treatments, and NHLBI research and clinical trials. Harvard. This site uses cookies to assist with navigation, analyse your use of our services, and provide content from third parties. or, by Trinity College Dublin. While asthma is well controlled in some people, around one-in-twelve patients respond poorly to current treatments. Although symptoms of mild asthma can be managed with current therapies, severe asthma remains very difficult to treat and asthma rates are constantly on the rise. We have found that Caspase-11 is a key driver of inflammation in the airways in asthma. Dr. Zaslona added: “A variety of irritants such as airborne pollutants, certain types of pollen and house dust mites can induce cell death in the lungs. Asthma is a pulmonary condition that causes the airways in your lungs to narrow and swell and produce additional mucus. This causes the signs and symptoms of asthma which most notably involves difficulty breathing.”. Medically reviewed by Cynthia Cobb, DNP, APRN — Written by Stephanie Watson — Updated on March 31, 2020. The researchers have uncovered a critical role for a protein (Caspase-11), which had previously never been implicated in the disease. Neither your address nor the recipient's address will be used for any other purpose. Researchers make asthma-Caspase-11 breakthrough February 26, 2020 ScienceBlog.com Researchers from Trinity College Dublin have made a breakthrough that may eventually lead to improved therapeutic options for people living with asthma. The American Lung Association is committed to funding asthma research. Daily science news on research developments and the latest scientific innovations, The latest engineering, electronics and technology advances, The most comprehensive sci-tech news coverage on the web. … The breakthrough is an inexpensive… Major asthma breakthrough as scientists discover root cause of the condition - and say a new treatment is less than 5 years away. Dr. Zaslona added: "A variety of irritants such as airborne pollutants, certain types of pollen and house dust mites can induce cell death in the lungs. Researchers from Trinity have made a breakthrough that may eventually lead to improved therapeutic options for people living with asthma. Symptoms include: wheezing; shortness of breath Apart from any fair dealing for the purpose of private study or research, no Research can improve the quality of everyday life for those diagnosed with asthma. Feature News . Lead author Zbigniew Zaslona, working with a team led by Luke O’Neill, Professor of Biochemistry in the School of Biochemistry and Immunology in the Trinity Biomedical Sciences Institute, has been exploring the role that inflammation plays in asthma—a very common and often serious disease of childhood. Researchers make asthma breakthrough February 26, 2020 Researchers from Trinity College Dublin have made a breakthrough that may eventually lead to improved therapeutic options for people living with asthma. Ireland has one of the highest incidences of asthma in Europe, which in its most severe form remains difficult to treat and can be fatal. As a result, your breathing becomes more difficult. Acute asthma attack is one of the most common causes of visits to hospital emergency departments in all age groups of the population and accounts for the greater part of healthcare burden from the disease. Asthma, like other chronic conditions,… The content is provided for information purposes only. National Prevalence of Asthma Attacks 1 among People with Current Asthma 2 by Age (2018) Characteristic Weighted number with asthma attack 1 Percent (SE) Total: 11,222,479: 45.4 (1.23) Child (Age <18 years) 2,965,929: 53.8 (2.70) Adult (Age 18+ years) 8,256,550: 43.0 (1.38) Science X Daily and the Weekly Email Newsletter are free features that allow you to receive your favorite sci-tech news updates in your email inbox, Using 'the language of cells' to find new treatments for asthma, allergies, Researchers identify mouse brain pathways active during feelings of empathy, IPhone12 will stop your implantable defibrillator, Study explores the effects of morning weather on people's mood and wellbeing at work, Biotin, mitochondria, and dementia: Research reveals a connection, Study explores the effects of immune responses on the aging brain. Our work suggests that Caspase-11 is sensing these noxious things and causing disease. Ireland has one of the highest incidences of asthma in Europe, which in its most severe form remains difficult to treat and can be fatal. Breakthrough on diarrhea virus opens up for new vaccines by Umea University Illustration from cryo-electron microscope image of the enteric adenovirus HAdV-F41. Consider allergic bronchopulmonary aspergillosis, gastroesophageal reflux, obesity, obstructive sleep apnea, rhinitis … asthma when there is a clear connection between symptoms and exposure to an allergen to which the patient is sensitive. The researchers have uncovered a critical role for a protein (Caspase-11), which had previously never been implicated in the disease. Your email address is used only to let the recipient know who sent the email. A new double-combination therapy that promotes lung expansion and airway clearance has been approved by the U.S. Food and Drug Administration (FDA) for the treatment of people with lung diseases including chronic obstructive pulmonary disease (COPD) and asthma. Get weekly and/or daily updates delivered to your inbox. 7 Incredible Health Breakthroughs Worth Celebrating in 2020 It was a devastating year in many ways, but 2020 also brought us life-changing developments. It may also trigger coughing, wheezing and/or shortness of breath. Bass, Kate. Researchers from Trinity College Dublin have made a breakthrough that may eventually lead to improved therapeutic options for people living with asthma… When this happens, it is likely to be a key driver of allergic inflammation in the lungs of asthmatics. The therapy was developed by the Monaghan Medical Corporation and combines two of their existing products — the … part may be reproduced without the written permission. Researchers claim major breakthrough in ... New range of asthma treatments could be available within five years after medical breakthrough ... February 26, 2020 11:25 am. We do not guarantee individual replies due to extremely high volume of correspondence. Breakthrough Drug Discovered For Asthma And COPD Treatment. According to Asthma UK, 5.4 million people in the UK are currently receiving treatment for asthma: 1.1 million children (1 in 11) and 4.3 million adults (1 in 12). Researchers Make Asthma Breakthrough . Lead author Zbigniew Zaslona, working with a team led by Luke O'Neill, Professor of Biochemistry in the School of Biochemistry and Immunology in the Trinity Biomedical Sciences Institute, has been exploring the role that inflammation plays in asthma—a very common and often serious disease of childhood. ", Professor O'Neill said: "Caspase-11—or it's human equivalent, which is Caspase-4—has never been implicated in asthma before so we think it holds great promise as a possible target for new drugs to treat this common, debilitating disease.". Click here to sign in with Determinants of Acute Asthma Attack among adult asthmatic patients visiting hospitals of Tigray, Ethiopia, 2019: case control study. by Pooja Shete on January 9, 2021 at 1:22 PM Drug News. You can unsubscribe at any time and we'll never share your details to third parties. Asthma is a chronic (long-term) condition that can cause the airways in the lungs to become inflamed and narrow. Researchers from Trinity College Dublin have made a breakthrough that may eventually lead to improved therapeutic options for people living with asthma. Researchers from Trinity College Dublin have made a breakthrough that may eventually lead to improved therapeutic options for people living with asthma. From Principia Scientific International Website The Asthma Treatment That Is Beating COVID-19 Published on July 23, 2020 Written by Alan Gray Dr. Richard Bartlett, a Dallas MD who previously advised Governor Rick Perry for 7 years has a lifesaving COVID breakthrough, that Taiwan, Japan, Singapore and Iceland are also using. Find more information in article, “Caspase-11 promotes allergic airway inflammation,” available at https://www.nature.com/articles/s41467-020-14945-2. When this happens, it is likely to be a key driver of allergic inflammation in the lungs of asthmatics. Asthma is a chronic inflammatory disease of the airways affecting more than 300 million patients worldwide. The information you enter will appear in your e-mail message and is not retained by Medical Xpress in any form. Your opinions are important to us. By Meryl Davids Landau More in … Treat comorbid conditions. Although symptoms of mild asthma can be managed with current therapies, severe asthma remains very difficult to treat and asthma rates are constantly on the rise. Five per cent of people with asthma don't respond to current treatments so research breakthroughs could be life changing for hundreds of thousands of people. Caspase-11 is a protein with an important role in defending against bacteria, but the team in Trinity has found that when it is over-active it can provoke a damaging inflammatory reaction. May 26, 2020 June 1, 2020 TalkingAsthma 1 min read . This causes the signs and symptoms of asthma which most notably involves difficulty breathing.". Asthma breakthrough: potential cause and corrective treatment are identified. Dr. Zaslona said: “Caspase-11 can cause cells to die, which is a very inflammatory event as the cells then release their contents, which can irritate tissues in our body. Researchers from Trinity College Dublin have made a breakthrough that may eventually lead to improved therapeutic options for people living with asthma. For others, they are life-threatening. By using our site, you acknowledge that you have read and understand our Privacy Policy The finding brings hope to the 300 million asthma … Researchers Make Asthma Breakthrough . Source: https://medicalxpress.com/news/2020-02-asthma-breakthrough.html, Tips for Kids With Exercise-Induced Asthma, Best Exercises for Asthma: Yoga, Swimming, Biking, and Walking, https://www.nature.com/articles/s41467-020-14945-2, https://medicalxpress.com/news/2020-02-asthma-breakthrough.html, New Asthma Medicine Insights Could Improve Future Treatment, Air Quality Dramatically Impacts Health Outcomes. and Terms of Use. You can be assured our editors closely monitor every feedback sent and will take appropriate actions. May 26, 2020 June 1, 2020 TalkingAsthma 438 Views 1 min read . 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