Hydrogen fluoride is listed on Annex I of Directive 67/548/EEC with R26/27/28 classification ('Very toxic by inhalation, in contact with skin and if swallowed'). Oral ingestion has very high mortality rate; Onset and severity of symptoms correlated with concentration Dilute solutions (<20%) may have delayed onset up to 24hr post-exposure A REVIEW OF THE INHALATION TOXICITY OF HYDROGEN FLUORIDE David P. Kelly Haskell Laboratory, DuPont Company Newark, DE 19714 USA The purpose of this talk is to review the toxicity of hydrogen fluoride especially as it pertains to health risks from accidental exposures. Low levels of fluorides can help prevent dental cavities. Like it’s sister, HCl acid, it reacts with water with the release of heat and can cause burns on the skin. Caution is advised. There is inconclusive animal data about toxic effects to a fetus. Basis for revised IDLH: Based on acute inhalation toxicity data in humans [Deichmann and Gerarde 1969; Largent 1961] and animals [Machle et al. Human exposure to HF can result in severe cutaneous manifestations as well as devastating systemic effects. It is also used as rust remover and in glass etching, metal cleaning, and petroleum processing. Hydrogen fluoride is a severe poison that may immediately and permanently damage lungs and the corneas of the eyes. All people who will be in the room while HF is in use must have completed training. Hydrogen fluoride will rapidly and extensively dissociate in the environmnet to form its constituent ions: hydrogen (hydronium) and fluoride. Brock Haskell Lahoratory, DuPont Company Newark, DE 19714 USA The purpose ofthis presentation is to review the toxicity of hydrogen fluoride (HF) especially ;IS it relates to health risks from accidental exposures, and review certain exposure limits that have been established for accidental releases. Signs and Symptoms of Acute Hydrogen Fluoride Exposure: Acute exposure to hydrogen fluoride will result in irritation, burns, ulcerous lesions, and necrosis of the eyes, skin, and mucous membranes. Hydrogen fluoride and fluorine are naturally-occurring gases that are very irritating to the skin, eyes, and respiratory tract. Effects may be delayed from 1 to 24 hours. Hydrogen fluoride (HF) is a byproduct of standard fire suppression systems. Hydrogen Fluoride is a very toxic chemical with serious long-term health consequences. The toxicity of the hydrogen (hydronium) ion will be apparent only at very high concentrations due to pH effects and is not considered to be relevant for the environmental risk assessment. Warning: Hydrogen fluoride is highly corrosive. Hydrogen fluoride is a gas which when in solution with water forms hydrofluoric acid, HF. Before any HF Use. HYDROGEN FLUORIDE: HOW TOXIC IS TOXIC? No data are available for acute oral toxicity. There is no evidence that hydrogen fluoride exposure causes cancer. (A HAZARD AND RISK ANALYSIS) William .I. Hydrogen fluoride gas will be absorbed by rain and into clouds and fog to form hydrofluoric acid, which will fall to the ground. Fluoride is deposited in the bone (fluorosis), and may cause pain and stiffness in joints and limbs. Fluorides are naturally occurring compounds. When combined with water, it is known as hydrofluoric acid. At high levels, fluorides can result in tooth and bone damage. Although a weak acid, i.e., it is not strongly disassociated, is used to etch glass. Inhalation Hydrogen fluoride (HF) is an extremely toxic substance commonly used in many industries such as textiles, pesticides, and semiconductors. 1934], the original IDLH for hydrogen fluoride (30 ppm) is not being revised at this time. 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